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BJOG. 2020 Mar 7. doi: 10.1111/1471-0528.16199. [Epub ahead of print]

Overweight and obesity status from the prenatal period to adolescence and its association with Non-alcoholic fatty liver disease in young adults: cohort study.

Author information

1
Instituto Nacional de Salud Pública, México.
2
Hospital General de México "Dr. Eduardo Liceaga", México.
3
Department of Radiology, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
4
Instituto Mexicano del Seguro Social, México.
5
Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", México.
6
Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
7
Department of Nutritional Sciences, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
8
Department of Environmental Health Sciences, University of Michigan, School of Public Health, Ann Arbor, MI, USA.
9
Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, USA.

Abstract

OBJECTIVE:

To examine the associations of maternal and child overweight status across multiple time-points with liver fat content in the offspring during young adulthood.

DESIGN:

Cohort study SETTING: ELEMENT Cohort in Mexico City POPULATION: Pregnant women with singleton births (n = 97) METHODS: We quantified hepatic triglyceride content (liver fat content) by proton magnetic resonance spectroscopy (1H MRS) and conventional T2-weighted MRIs (3T scanner) in 97 young adults from the ELEMENT birth cohort in Mexico City. Historical records of the cohort were used as a source of pregnancy, childhood and adolescence anthropometric information, overweight and obesity (OWOB) were defined. Adjusted structural equation models were run to identify the association between OWOB in different life stages with liver fat content (log-transformed) in young adulthood.

MAIN OUTCOME:

Maternal OWOB at the time of delivery was directly and indirectly associated with the liver fat content in the offspring at young adulthood.

RESULTS:

Seventeen percent of the participants were classified as having NAFLD. We found a strong association of OWOB between all periods assessed. Maternal OWOB at time of delivery (β=1.97 95%CI 1.28, 3.05), and OWOB status in the offspring at young adulthood (β=3.17, 95%CI 2.10, 4.77) were directly associated with the liver fat content in the offspring. Also, maternal OWOB was indirectly associated with liver fat content through offspring OWOB status.

CONCLUSION:

We found that maternal OWOB status is related to fatty liver content in the offspring as young adults, even after taking into account OWOB status and lifestyle factors in the offspring.

KEYWORDS:

cohort; liver fat content; maternal overweight

PMID:
32145139
DOI:
10.1111/1471-0528.16199

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