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Indian J Cancer. 2020 Jan-Mar;57(1):93-97. doi: 10.4103/ijc.IJC_361_18.

Scrambler therapy: A ray of hope for refractory chemotherapy-induced peripheral neuropathy.

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Department of Onco-Anaesthesia and Palliative Medicine, Dr. B R Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.


Scrambler therapy (ST) is a novel noninvasive modality for treatment of chronic neuropathic and cancer pain using 5 artificial neurons. The principle with Scrambler Therapy is that synthetic "non-pain" information is transmitted by C fiber surface receptors. Chemotherapy-induced peripheral neuropathy can markedly deteriorate patient's quality of life and can also negatively affect compliance with the anticancer treatment. Chronic neuropathic pain presents a therapeutic challenge if resistant to pharmacological management opioids and other types of treatments. We have described here successful use of scrambler therapy in three cases of chemotherapy-induced peripheral neuropathy.


Chemotherapy-induced peripheral neuropathy; pharmacological management; refractory

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