Format

Send to

Choose Destination
Eur J Prev Cardiol. 2020 Mar 3:2047487320909300. doi: 10.1177/2047487320909300. [Epub ahead of print]

Systematic Coronary Risk Evaluation estimated risk and prevalent subclinical atherosclerosis in coronary and carotid arteries: A population-based cohort analysis from the Swedish Cardiopulmonary Bioimage Study.

Author information

1
Department of Medical and Health Sciences, Linköping University, Sweden.
2
Department of Public Health and Clinical Medicine, Umeå University, Sweden.
3
Department of Cardiology, Sahlgrenska University Hospital, Sweden.
4
Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden.
5
Department of Clinical Physiology, Sahlgrenska University Hospital, Sweden.
6
Department of Radiology, Sahlgrenska University Hospital, Sweden.
7
Department of Radiology, University of Gothenburg, Sweden.
8
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Sweden.
9
Department of Clinical Sciences in Malmö, Lund University, Sweden.
10
Department of Clinical Sciences Lund, Lund University, Sweden.
11
Skåne University Hospital, Sweden.
12
Department of Medical Sciences, Uppsala University, Sweden.
13
Uppsala Clinical Research Center, Uppsala University, Sweden.
14
Department of Medicine, Karolinska University Hospital, Sweden.
15
Centre of Medical Image Science and Visualization, Linkoping University, Sweden.
16
Department of Radiology, Linköping University, Sweden.
17
Department of Clinical Sciences, Danderyd University Hospital, Sweden.
18
Sahlgrenska University Hospital, Sweden.
19
The George Institute for Global Health, University of New South Wales, Australia.
20
Department of Cardiology, Linköping University, Sweden.
21
Department of Clinical Physiology, Linköping University, Sweden.

Abstract

BACKGROUND:

It is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and prevalent subclinical atherosclerosis.

DESIGN:

The design of this study was as a cross-sectional analysis from a population-based study cohort.

METHODS:

From the general population, the Swedish Cardiopulmonary Bioimage Study randomly invited individuals aged 50-64 years and enrolled 13,411 participants mean age 57 (standard deviation 4.3) years; 46% males between November 2013-December 2016. Associations between Systematic Coronary Risk Evaluation risk estimates and coronary artery calcification and plaques in the carotid arteries by using imaging data from a computed tomography of the heart and ultrasonography of the carotid arteries were examined.

RESULTS:

Coronary calcification was present in 39.5% and carotid plaque in 56.0%. In men, coronary artery calcium score >0 ranged from 40.7-65.9% and presence of carotid plaques from 54.5% to 72.8% in the age group 50-54 and 60-65 years, respectively. In women, the corresponding difference was from 17.1-38.9% and from 41.0-58.4%. A doubling of Systematic Coronary Risk Evaluation was associated with an increased probability to have coronary artery calcium score >0 (odds ratio: 2.18 (95% confidence interval 2.07-2.30)) and to have >1 carotid plaques (1.67 (1.61-1.74)).

CONCLUSION:

Systematic Coronary Risk Evaluation estimated risk is associated with prevalent subclinical atherosclerosis in two major vascular beds in a general population sample without established cardiovascular disease or diabetes mellitus. Thus, the Systematic Coronary Risk Evaluation risk chart may be of use for estimating the risk of subclinical atherosclerosis.

KEYWORDS:

Systematic Coronary Risk Evaluation; atherosclerosis; estimated risk; population; subclinical

PMID:
32126830
DOI:
10.1177/2047487320909300

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center