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Medicine (Baltimore). 2020 Feb;99(9):e19232. doi: 10.1097/MD.0000000000019232.

Assessment of biotin interference in thyroid function tests.

Author information

1
Department of Endocrinology.
2
Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University.
3
Department of Radiotherapy, The Tumor Hospital of Jilin Province.
4
Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, China.

Abstract

The aim of the study was to systematically characterize the interference of biotin on thyroid function tests and biotin washout periods.Ten healthy adults were recruited with administration of 5 and 10 mg/d biotin for 7 days. Analyte concentrations of thyroid function tests were measured at baseline prior to starting biotin and from 2 hours to 2 days after withdrawal of 5 and 10 mg/d biotin. The outcomes were compared the baseline with the several points after taking biotin at Roche cobas e602, Beckman UniCel DxI 800, and Abbott Architect 2000 immunoassay platforms, respectively.Ingesting 5 or 10 mg/d of biotin for 7 days could produce positive or negative interference among the thyroid function tests at Roche cobas e602 and Beckman UniCel DxI 800 systems, but no interference on Abbott Architect 2000. Interference duration of 5 mg/d biotin for Roche cobas e602 and Beckman UniCel DxI 800 of thyroid function tests lasted for 8 hours, while 10 mg/d biotin interfered with Roche cobas e602 or Beckman UniCel DxI 800 for 1 day or 2 days.This study provides valuable guidance on biotin washout periods at doses common in over-the-counter supplements necessary to avoid false assay results.Trial registration: ChiCTR1800020472.

PMID:
32118725
DOI:
10.1097/MD.0000000000019232
[Indexed for MEDLINE]
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