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Drug Discov Ther. 2020 Mar 8;14(1):54-57. doi: 10.5582/ddt.2020.01003. Epub 2020 Feb 28.

Efficacy of Chinese prescription Kangen-karyu for patient with metabolic syndrome.

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Shinseikai Toyama Hospital, Toyama, Japan.
Department of Medicinal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong, Republic of Korea.
Department of Food and Life Science, Pukyong National University, Busan, Republic of Korea.
Graduate School of Science and Engineering for Research, University of Toyama, Toyama, Japan.


Metabolic syndrome is a cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus. The risk factors include hypertension, dyslipidemia, hyperglycemia, and central obesity. Various diagnostic criteria have been proposed by different organizations over the past decade. The utilization of traditional Chinese medicine to treat metabolic syndrome has received increasing attention due to its wide availability. In this paper, we report the case of a 68-year-old patient with hypertension, hypercholesterolemia, borderline diabetes, and obesity, who showed an improvement in metabolic syndrome on the administration of 7.5 g of Kangen-karyu extract per day. After 6 months, the levels of serum total cholesterol, low-density lipoprotein-cholesterol, triglycerides, hemoglobin A1c were decreased. The abdominal circumference and body weight were decreased following administration. At that time, the somatic and subjective symptoms had partially disappeared. Herein, we present and discuss the evidence supporting the use of Kangen-karyu extract against metabolic syndrome.


Kangen-karyu; Metabolic syndrome; case report; traditional Chinese medicine

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