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Indian J Pathol Microbiol. 2020 Feb;63(Supplement):S134-S140. doi: 10.4103/IJPM.IJPM_757_18.

Mammary analogue secretory carcinoma: An Indian experience of a novel entity.

Author information

The Oncopathology Centre, Mahatma Gandhi Cancer Hospital, Miraj, Maharashtra, India.
Department of Pathology, Shri Siddhivinayak Ganapati Cancer Hospital, Miraj, Maharashtra, India.



To explore clinical, histopathological and immunohistochemistry (IHC) features of mammary analogue secretory carcinoma (MASC) with systematic literature review.

Settings and Design:

Hospital based cross-sectional study.

Subjects and Methods:

The data of all cases of MASC diagnosed over a period of 1 year i.e., from July 2017 to July 2018 were retrieved. The haematoxylin and eosin (H and E) sections, and IHC sections were studied. A strict histological and recently updated criteria were applied and patients with a confirmed diagnosis of MASC were included in the study. A systematic literature review was conducted by searching the PubMed and National Centre for Biotechnology Information database.

Statistical Analysis Used:

Microsoft Excel 2010.


The present case series is 27th in the English literature and 1stcase series describing its histopathology in the Indian literature. The mean age of presentation is 43 years. Female preponderance was found i.e., M:F ratio of 0.5.


Histopathology and if necessary, followed by IHC is required for the confirmation of diagnosis of MASC. We should be aware about this recently described entity which is usually mistaken for other low grade salivary gland carcinomas like Acinic cell carcinoma (AciCC) and Mucoepidermoid carcinoma (MEC). The knowledge about its typical morphology, high degree of suspicion and IHC confirmation with both S-100 and Mammaglobin help in precise diagnosis.


ETV6-NTRK3 gene fusion; mammaglobin; mammary analogue secretory carcinoma

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