Format

Send to

Choose Destination
Indian J Pathol Microbiol. 2020 Feb;63(Supplement):S81-S86. doi: 10.4103/IJPM.IJPM_340_19.

Uterine tumor resembling ovarian sex cord tumor: A series of six cases displaying varied histopathological patterns and clinical profiles.

Author information

1
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
2
Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.
3
Department of Radiology, All India Institute of Medical Sciences, New Delhi, India.

Abstract

Introduction:

Uterine tumors resembling ovarian sex cord tumor (UTROSCT) are a unique group of neoplasms with diverse morphology and immunophenotypic characteristics, coexpressing sex cord, epithelial, and smooth-muscle markers. To date, less than 100 cases have been reported and there is paucity of data concerning their clinical behavior.

Materials and Methods:

All cases of uterine body tumors diagnosed over a period of two and a half years (2016-2018) were retrieved. Histopathological features were reviewed and extended panel of immunohistochemistry was performed to identify cases of UTROSCTs.

Results:

Six cases of UTROSCTs were identified with a median age of 46.5 years. Four of them presented with menorrhagia, while two with postmenopausal bleeding including one with a history of carcinoma breast. Three of these cases were initially misdiagnosed as endometrial stromal sarcoma and adenocarcinomas. They all underwent hysterectomy with bilateral salpingo-oophorectomy.

Conclusion:

It is considered a tumor with low malignant potential; however, one out of six cases (16.7%) in our study showed metastasis, within 1 year of diagnosis. It is important to recognize this entity as it mimics a wide range of both benign and malignant tumors. Molecular pathogenesis and exact management protocols remain elusive due to rarity,hence, multi-institutional studies are warranted.

KEYWORDS:

Mesenchymal neoplasm; ovarian; sex cord stromal; uterus

PMID:
32108635
DOI:
10.4103/IJPM.IJPM_340_19
Free full text

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd
Loading ...
Support Center