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Indian J Pathol Microbiol. 2020 Feb;63(Supplement):S30-S33. doi: 10.4103/IJPM.IJPM_467_18.

Immunoexpression of estrogen receptor-β and progesterone receptor in prostate adenocarcinoma, does it inhibit neoplastic proliferation and invasion?

Author information

1
Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, Delhi, India.
2
Department of Urology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, Delhi, India.

Abstract

Context:

The roles of estrogen and progesterone in human prostate carcinogenesis have been only recently recognized.

Aims:

This study was conducted to evaluate the expressions of esterone receptor-beta (ER-β), progesterone receptor (PR), and Ki-67 in benign and malignant lesions of the prostate.

Settings and Design:

The study was conducted at a tertiary care hospital. It was an analytical cross-sectional study.

Materials and Methods:

We selected a total of 39 cases including 26 cases of benign prostatic hyperplasia and 13 cases of adenocarcinoma prostate. The proportion of cases showing expression for ER-β, PR, and Ki-67 was noted for both groups. A difference in immunoexpression between benign and malignant cases was evaluated. Association between receptor expression and Gleason grade was evaluated for malignant cases.

Statistical Analysis Used:

To compare the difference in expressions of ER-β, PR, and Ki-67 Mann-Whitney U test was used. Association between ER-β, PR, and Ki-67 expression and Gleason grade was analyzed using the Chi-square test.

Results:

ER-β expression was seen in all benign and malignant cases, whereas the majority of the malignant cases (61.54%) were negative for progesterone expression. Epithelial expressions of ER-β and PR were significantly higher in benign as compared with malignant lesions. Malignant cases showed a significantly higher expression of Ki-67. However, we did not find any association between the expressions of these markers with Gleason grade.

Conclusions:

The expressions of ER-β and PR were significantly higher in the epithelium in benign cases as compared with malignant cases. Ki-67 expression was significantly higher in the malignant group as compared with the benign group.

KEYWORDS:

Estrogen receptor-beta; Ki-67; progesterone receptor; prostate carcinoma

PMID:
32108623
DOI:
10.4103/IJPM.IJPM_467_18
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