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Rev Alerg Mex. 2019 Oct-Dec;66(4):504-509. doi: 10.29262/ram.v66i4.587.

[Mast cell activation syndrome. About a clinical case].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Medellín, Colombia. rcv2016udea@gmail.com.

Abstract

in English, Spanish

BACKGROUND:

Monoclonal mast cell activation syndrome is included in mast cell activation disorders in which, after a diagnostic process, it is not possible to meet the required criteria for a diagnosis of systemic mastocytosis.

CLINICAL CASE:

A 73-year-old woman who presented two events of anaphylaxis 15 minutes after the intake of yucca; with a positive skin test, elevated tryptase, and mast cells with abnormal phenotype in the bone marrow biopsy, and without criteria for systemic mastocytosis.

CONCLUSION:

The diagnosis of monoclonal mast cell activation syndrome requires high clinical suspicion for patients with recurrent anaphylaxis and elevated tryptase, for whom joint management with hematology is essential.

KEYWORDS:

Anaphylaxis; Mastocytosis; Tryptase

PMID:
32105433
DOI:
10.29262/ram.v66i4.587

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