Send to

Choose Destination
Drug Discov Ther. 2020 Mar 8;14(1):50-53. doi: 10.5582/ddt.2019.01091. Epub 2020 Feb 26.

Association of moderately abnormal behavior and administered neuraminidase inhibitors.

Author information

Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.
National Hospital Organization Mie National Hospital, Mie, Japan.
Fukuoka Welfare Center for the Disabled, Fukuoka, Japan.
Ryoumou Seishi Ryogoen for the Severely Disabled, Gunma, Japan.
Kawasaki City Institute for Public Health, Kawasaki, Japan.


Our earlier study investigated the incidence of severe abnormal behavior associated with neuraminidase inhibitors (NIs), but some studies have specifically examined the association of oseltamivir use and moderately abnormal behavior. Therefore, this study was undertaken to assess associations between moderately abnormal behavior and administered drugs. All cases of patients with influenza who exhibited moderately abnormal behavior were reported to us by physicians of all sentinel clinics and hospitals for influenza throughout Japan. Open Data of the National Database of Electronic Medical Claims include the numbers of patients diagnosed as having influenza who were prescribed NI. Incidence by NI was tested using Fisher's exact test. We received 518 moderately abnormal cases in 5-9-year-olds and 207 moderately abnormal behavior cases in 10-19-year-olds. The incidence among NI ranged from 193 per one million influenza patients in laninamivir among 10-19-year-olds to 1021 for peramivir among 5-9-year-olds. Estimation results revealed the order of risk among NIs as peramivir, oseltamivir, zanamivir and laninamivir in moderate abnormal behavior. Because of data limitations, risk among patients with and without NI cannot be compared.


Moderately abnormal behavior; incidence; influenza; neuraminidase inhibitors; relative risk

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center