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J Med Virol. 2020 Feb 26. doi: 10.1002/jmv.25725. [Epub ahead of print]

Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection.

Author information

1
Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.

Abstract

OBJECTIVE:

This study aimed to assess the presence of novel coronavirus in tears and conjunctival secretions of SARS-CoV-2-infected patients.

METHODS:

A prospective interventional case series study was performed, and 30 confirmed novel coronavirus pneumonia (NCP) patients were selected at the First Affiliated Hospital of Zhejiang University from 26 January 2020 to 9 February 2020. At an interval of 2 to 3 days, tear and conjunctival secretions were collected twice with disposable sampling swabs for reverse-transcription polymerase chain reaction (RT-PCR) assay.

RESULTS:

Twenty-one common-type and nine severe-type NCP patients were enrolled. Two samples of tear and conjunctival secretions were obtained from the only one patient with conjunctivitis yielded positive RT-PCR results. Fifty-eight samples from other patents were all negative.

CONCLUSION:

We speculate that SARS-CoV-2 may be detected in the tears and conjunctival secretions in NCP patients with conjunctivitis.

KEYWORDS:

coronavirus; horizontal transmission; infection

PMID:
32100876
DOI:
10.1002/jmv.25725

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