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J Autism Dev Disord. 2020 Feb 24. doi: 10.1007/s10803-020-04414-6. [Epub ahead of print]

Psychiatric and Medical Profiles of Autistic Adults in the SPARK Cohort.

Collaborators (304)

Abbeduto L, Aberbach G, Acampado J, Ace AJ, Albright C, Alessandri M, Amaral DG, Amatya A, Anglo C, Annett RD, Arriaga I, Ashley R, Astrovskaya I, Baalman K, Baer M, Bahl E, Balasubramanian A, Baraghoshi G, Bardett N, Barnard RA, Bashar A, Beaudet A, Beckwith M, Beeson L, Bentley D, Bernier RA, Berry-Kravis E, Boland S, Booker S, Bradley C, Brewster SJ, Brooks E, Brown M, Brueggeman L, Butler ME, Butter EM, Callahan K, Camba A, Carbone P, Carpenter L, Carpenter S, Carriero N, Cartner LA, Casten L, Chatha AS, Chin W, Chintalapalli S, Cho D, Chung WK, Clark RD, Cohen C, Coleman K, Columbi C, Coppola L, Courchesne E, Cubells JF, Currin MH, Daniels AM, David G, DeMarco L, Dennis MY, Dent K, Dichter GS, Ding Y, Dinh H, Doan R, Doddapaneni H, Eichler EE, Eldred S, Eng C, Erickson CA, Esler A, Fatemi A, Feliciano P, Fischer G, Fish A, Fisk I, Fombonne EJ, Foster M, Fox EA, Francis S, Friedman SL, Ganesan S, Garrett M, Gazestani V, Geisheker MR, Gerdts JA, Geschwind DH, Ghaziuddin M, Gibbs RA, Goin-Kochel RP, Gonzalez N, Goudreau L, Griswold AJ, Grosvenor LP, Gruber AJ, Gulsrud AC, Gunderson J, Gunter C, Gupta A, Gutierrez A, Hale MN, Haley M, Hall JB, Hamer KE, Han B, Hanna N, Hardan A, Harkins C, Harrington G, Harris J, Harris N, Hauf B, Hayes C, Heerwagen K, Hepburn SL, Herbert LM, Heyman M, Higgins L, Hilscher BA, Hofammann E, Hojlo M, Horner S, Hsieh A, Hu J, Huang-Storms LY, Hunter S, Hutter H, Istephanous D, Jacob S, Jaramillo N, Jelinek A, Jensen W, Jones M, Jordy M, Jorgenson A, Jou R, Pablo Juarez A, Judge J, Jurayj J, Kalmus T, Kanne S, Kaplan HE, Kasparson L, Kent M, Kim SH, Kitaygorodsky A, Koene H, Koomar T, Korchina V, Krentz AD, Schneider HL, Lamarche E, Lampert E, Landa RJ, Lash AE, Law JK, Lawson N, Layman K, Lechniak H, Lee S, Lee SJ, Coury DL, Martin CL, Lesher L, Li H, Li D, Lillie N, Liu X, Lopez M, Lord C, Lowe K, Mallardi MD, Manning P, Manoharan J, Marini R, Martin C, Marzano G, Mason A, Mastel S, Matthews ET, McCracken JT, McKenzie AP, Miceli A, Michaelson JJ, Milliken A, Mohiuddin S, Momin Z, Morrier MJ, Mostofsky S, Murali S, Muzny D, Myers VJ, Neely J, Nessner C, Nicholson A, Niederhouser M, O'Brien K, O'Connor E, O'Neil M, O'Roak BJ, Ochoa-Lubinoff C, Orobio J, Orrick L, Ortiz C, Ousley OY, Pacheco LD, Palmer S, Pandey J, Paolicelli AM, Pawlowski KG, Pierce KL, Piven J, Plate S, Polanco J, Popp M, Pottschmidt N, Pramparo T, Prock LM, Qi H, Qiu S, Rachubinski AL, Rajbhandari K, Rana R, Ranganathan V, Raymond L, Remington R, Rice CE, Rigby C, Robertson BE, Rodriguez N, Rodriguez B, Roeder K, Rosenberg CR, Russo-Ponsaran N, Ruzzo E, Sabo A, Sahin M, Salomatov A, Sandhu S, Santangelo S, Sarver DE, Scherr J, Schultz RT, Schweers KA, Shaffer R, Shah S, Shaikh T, Shen Y, Shocklee AD, Shulman L, Siegel M, Simon AR, Simon L, Singh V, Skinner S, Smith CJ, Smith K, Green Snyder L, Soorya LV, Soucy A, Stamps D, Steele M, Stephens AN, Stock CM, Sullivan C, Sutcliffe JS, Sutcliffe JS, Swanson A, Tafolla M, Takahashi N, Taylor C, Thomas C, Thomas T, Thompson S, Tjernagel J, Turner TN, Valicenti-McDermott M, Van Metre B, Van Wade C, Veenstra-Vanderweele J, Verdi M, Vernoia BM, Volfovsky N, Wallace J, Walston CH, Wang J, Wang T, Warren Z, Wasserburg L, White S, Casey White-Lehman L, Wodka EL, Xu S, Yang WS, Yinger M, Youngkin S, Yu T, Zang L, Zaydens H, Zhang H, Zhao H, Zhou X, Zick A.

Author information

1
Departments of Psychiatry, Pediatrics & Behavioral Neuroscience, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA. fombonne@ohsu.edu.
2
The Simons Foundation, New York, NY, USA.
3
Department of Pediatrics, Columbia University Medical Center, New York, NY, USA.

Abstract

This study examined lifetime medical and psychiatric morbidity reported by caregivers of 2917 autistic adults participating in the US research cohort SPARK. Participants were 78.4% male, 47.3% had intellectual disability, and 32.1% had persistent language impairments. Childhood language disorders (59.7%), speech/articulation problems (32.8%), sleep (39.4%) and eating problems (29.4%), motor delays (22.8%) and history of seizure (15.5%) were the most frequently reported clinical features. Over two thirds (67.2%) had been diagnosed with at least one psychiatric disorder (anxiety disorders: 41.1%; ADHD: 38.7%). Compared to verbally fluent participants, those with language impairments had lower frequencies of almost all psychiatric disorders. Female sex and older age were associated with higher medical and psychiatric morbidity.

KEYWORDS:

Adult; Autism; Autism spectrum disorder; Intellectual disabilities; Medical; Psychiatric; SPARK; Sex

PMID:
32096123
DOI:
10.1007/s10803-020-04414-6

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