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J Appl Physiol (1985). 1988 Nov;65(5):2245-52.

Exercise selectively increases G4 AChe activity in fast-twitch muscle.

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Neuroscience Research laboratory, Veterans Administration Medical Center, Kansas City, Missouri 64128.


Acetylcholinesterase (AChe) molecular forms were studied in hindlimb skeletal muscles from adult male Fischer 344 rats subjected to treadmill exercise for periods ranging between 1 and 30 days. Groups of three animals were exercised for 1 h/day at a treadmill speed of 8.5 m/min, with 1-min sprints at 15 m/min every 10 min. This exercise protocol led to a significant increase in the activity of G4 AChe in fast-twitch (gracilis and tibialis) but not in slow-twitch (soleus) muscles. Other AChe forms and muscle protein content remained unaltered. Such a selective enzymatic change was detected after a single exercise session, became more apparent after three daily sessions, and persisted for at least 30 days of exercise. A larger increment in G4 AChe activity was observed in gracilis muscle end-plate vs. non-end-plate regions. These findings show a specific adaptive reaction of fast-twitch muscles to enhanced motor activity, suggest that individual AChe forms in motor end plates are regulated through separate mechanisms, and support the hypothesis that membrane-bound G4 AChe plays an essential role in neuro-muscular transmission.

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