Send to

Choose Destination
Phytother Res. 2020 Feb 21. doi: 10.1002/ptr.6639. [Epub ahead of print]

Quality of Life, Mental Health, Personality and Patterns of Use in Self-Medicated Cannabis Users with Chronic Diseases: A 12-Month Longitudinal Study.

Author information

ICEERS-International Center for Ethnobotanical Education, Research and Service, Barcelona, Spain.
Department of Anthropology, Philosophy and Social Work, Universitat Rovira i Virgili, Medical Anthropology Research Center, Tarragona, Spain.
Department of Neurosciences and Behavior, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
National Institute for Translational Medicine (INCT-TM), CNPq, Ribeirão Preto, São Paulo, Brazil.
Faculty of Pharmaceutical Sciences, Department of Clinical and Toxicological Analyses, Sao Paulo University, Sao Paulo, Brazil.
Department of Biological and Health Psychology, School of Psychology, Madrid Autonomous University, Madrid, Spain.
Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Department of Pharmacology, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Spain.


The number of patients using cannabis for therapeutic purposes is growing worldwide. While research regarding the treatment of certain diseases/disorders with cannabis and cannabinoids is also expanding, only a few longitudinal studies have assessed the mid-term impacts of medical cannabis use on psychological variables and quality of life (QoL). The aim of the study was to assess the psychological safety and QoL of patients with chronic diseases who self-medicate with cannabis over time. We recruited patients with various chronic diseases who use cannabis and collected data regarding patterns of cannabis use as well as mental health, personality and QoL. Participants were followed-up at baseline, 4, 8 and 12 months. Hair analysis was conducted to confirm the presence of cannabinoids. Personality assessment showed a consistent decrease in self-transcendence and self-directedness scores. Neither cognitive nor psychopathological deterioration was found. There were also no variations in QoL. Mid-term use of medical cannabis seems to show adequate tolerability regarding cognitive and psychopathological abilities, and it may help patients with chronic diseases to maintain an acceptable QoL.


cannabis; chronic disease; medical cannabis; mental health; quality of life


Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center