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Acad Pathol. 2020 Feb 6;7:2374289520903415. doi: 10.1177/2374289520903415. eCollection 2020 Jan-Dec.

Educational Case: Gastric High-Grade B-Cell Lymphoma With MYC and BCL2 Gene Rearrangement (Double-Hit Lymphoma).

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Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA, USA.


The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see


BCL2; C-MYC; gastric ulcer; hematopathology; high-grade lymphoma; organ system pathology; pathology competencies; white cell disorder

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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