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Brain Res. 1988 Aug 16;458(1):132-6.

Intraventricular injection of antiserum to nerve growth factor delays the development of amygdaloid kindling.

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Department of Physiology, Yokohama City University School of Medicine, Japan.


To investigate the possibility that nerve growth factor (NGF) may play some role in the development of kindling, rabbit anti-NGF serum was injected into the third ventricle on the first 3 days of daily electrical stimulation of the basolateral amygdala. The number of stimulations required to reach full amygdaloid kindling increased significantly in the rat injected with anti-NGF serum compared to that in the rat injected with normal rabbit serum. It was confirmed that anti-NGF serum did not act as an anticonvulsant. The results demonstrate that NGF may be important for the long-lasting neuronal changes induced by daily electrical stimulation of the amygdala.

[Indexed for MEDLINE]

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