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J Pediatr Hematol Oncol. 2020 Feb 19. doi: 10.1097/MPH.0000000000001749. [Epub ahead of print]

The Management of Young Children With a Likely Infectious Condition Presenting Moderate to Severe Neutropenia.

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Department of Pediatrics.
Clinical and Evaluative Research Platform, Research Center, CHU de Québec-Université Laval.
Population Health and Optimal Health Practices Research Branch, CHU de Québec Research Centre, Québec City, QC, Canada.



The objective of this study was to describe the outcome of healthy children presenting with newly-diagnosed neutropenia in an infectious context.


A total of 184 episodes of neutropenia were included in children aged 3 months to 5 years. There were 118 (64%) episodes of moderate neutropenia and 66 (36%) of severe neutropenia (SN). SN episodes were more likely related to intensification of antibiotic regimen used and further investigations. The median duration of neutropenia was 8.5 days. Chronic benign neutropenia occurred in 7 (4%) patients.


SN led to intensification of antibiotic therapy, but no children encountered an unfavorable outcome and the neutropenia episodes were short-lived.

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