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Biol Neonate. 1988;54(1):45-8.

Effect of bupivacaine hydrochloride on bilirubin production in neonatal rats.

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Department of Pediatrics, Stanford University School of Medicine, Calif.


The rate of bilirubin production was studied in 12-hour-old rats exposed to bupivacaine HCl by subcutaneous injection. The bilirubin production was estimated by measuring the excretion rate of carbon monoxide (VeCO) using an open flow-through system. No significant difference was found between the VeCO of bupivacaine HCl-treated and control animals, or between the levels of bilirubin in the pooled blood of treated (0.92 +/- 0.32 SE mg/dl) and control (1.0 +/- 0.28 SE mg/dl) animals. These negative findings support the clinical studies which have not demonstrated an association between epidural anesthesia with bupivacaine HCl and neonatal jaundice.

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