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J Perinatol. 2020 Feb 17. doi: 10.1038/s41372-020-0614-4. [Epub ahead of print]

Medications and in-hospital outcomes in infants born at 22-24 weeks of gestation.

Author information

1
Department of Pediatrics, University of Washington, Seattle, WA, USA.
2
Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.
3
Department of Economics, Clemson University, Clemson, SC, USA.
4
Duke Clinical Research Institute, Durham, NC, USA.
5
MEDNAX Center for Research, Education, Quality and Safety, San Antonio, TX, USA.
6
Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. rachel.greenberg@duke.edu.
7
Duke Clinical Research Institute, Durham, NC, USA. rachel.greenberg@duke.edu.

Abstract

OBJECTIVE:

To evaluate the most commonly used medications and in-hospital morbidities and mortality in infants born 22-24 weeks of gestation.

STUDY DESIGN:

Multicenter retrospective cohort study of infants born 22-24 weeks of gestation (2006-2016), without major congenital anomalies and with available medication data obtained from neonatal intensive care units managed by the Pediatrix Medical Group.

RESULTS:

This study included 7578 infants from 195 sites. Median (25th, 75th percentile): birthweight was 610 g (540, 680); the number of distinct medications used was 13 (8, 18); and different antimicrobial exposure was 4 (2, 5). The most common morbidities were BPD (41%) and grade III or IV IVH (20%), and overall survival varied from 46% (2006) to 57% (2016).

CONCLUSIONS:

A large number of medications were used in periviable infants. There was a high prevalence of in-hospital morbidities, and survival of this population increased over the study period.

PMID:
32066843
DOI:
10.1038/s41372-020-0614-4

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