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Acad Pathol. 2020 Jan 30;7:2374289520901809. doi: 10.1177/2374289520901809. eCollection 2020 Jan-Dec.

Educational Case: Opportunistic Infections of the Central Nervous System.

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University of Florida, College of Medicine, Gainesville, FL, USA.
Department of Pathology, University of Florida Health, Gainesville, FL, USA.


The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see


Cryptococcus; central nervous system; cytomegalovirus; human polyomavirus 2 (JC virus); infections; organ system pathology; pathology competencies; toxoplasmosis; tuberculosis

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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