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Antiviral Res. 2020 Apr;176:104742. doi: 10.1016/j.antiviral.2020.104742. Epub 2020 Feb 10.

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.

Author information

1
Unité des Virus Émergents (UVE: Aix-Marseille Univ - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France.
2
Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.
3
Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM, Affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada.
4
Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France. Electronic address: etienne.decroly@afmb.univ-mrs.fr.

Abstract

In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.

KEYWORDS:

2019-nCoV; Antivirals; Furin; Maturation protease; SARS-CoV; Spike protein

PMID:
32057769
DOI:
10.1016/j.antiviral.2020.104742
[Indexed for MEDLINE]

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