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Radiology. 2020 Feb 12:200343. doi: 10.1148/radiol.2020200343. [Epub ahead of print]

Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing.

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From the Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, China (X.X., W.Z., J.L.); Department of Radiology Quality Control Center, Changsha, Hunan Province, 410011, China (J.L.); Department of Radiology, First hospital of Changsha, Hunan Province, 410005, China (Z.Z.); Changsha public health treatment center, Hunan Province, 410153, China (Z.Z.); Department of Radiology,The first people's hospital of Changde city, Hunan Province,415003,China (C.Z.); and Department of Radiology,The second people's hospital of Changde city, Hunan Province,415001,China (F.W.).


Some patients with positive chest CT findings may present with negative results of real time reverse-transcription-polymerase chain- reaction (RT-PCR) for 2019 novel coronavirus (2019-nCoV). In this report, we present chest CT findings from five patients with 2019-nCoV infection who had initial negative RT-PCR results. All five patients had typical imaging findings, including ground-glass opacity (GGO) (5 patients) and/or mixed GGO and mixed consolidation (2 patients). After isolation for presumed 2019-nCoV pneumonia, all patients were eventually confirmed with 2019-nCoV infection by repeated swab tests. A combination of repeated swab tests and CT scanning may be helpful when for individuals with high clinical suspicion of nCoV infection but negative RT-PCR screening.


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