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Biophys J. 2020 Jan 17. pii: S0006-3495(20)30031-X. doi: 10.1016/j.bpj.2020.01.008. [Epub ahead of print]

Geometric Dependence of 3D Collective Cancer Invasion.

Author information

1
Department of Physics, Oregon State University, Corvallis, Oregon.
2
Department of Physics, Arizona State University, Tempe, Arizona.
3
Materials Science and Engineering, Arizona State University, Tempe, Arizona.
4
Materials Science and Engineering, Arizona State University, Tempe, Arizona; Department of Physics, Qufu Normal University, Qufu, China.
5
Department of Physics, Arizona State University, Tempe, Arizona; Materials Science and Engineering, Arizona State University, Tempe, Arizona. Electronic address: jiao.2@asu.edu.
6
Department of Physics, Oregon State University, Corvallis, Oregon. Electronic address: sunb@onid.orst.edu.

Abstract

Metastasis of mesenchymal tumor cells is traditionally considered as a single-cell process. Here, we report an emergent collective phenomenon in which the dissemination rate of mesenchymal breast cancer cells from three-dimensional tumors depends on the tumor geometry. Combining experimental measurements and computational modeling, we demonstrate that the collective dynamics is coordinated by the mechanical feedback between individual cells and their surrounding extracellular matrix (ECM). We find the tissue-like fibrous ECM supports long-range physical interactions between cells, which turn geometric cues into regulated cell dissemination dynamics. Our results suggest that migrating cells in three-dimensional ECM represent a distinct class of an active particle system in which the collective dynamics is governed by the remodeling of the environment rather than direct particle-particle interactions.

PMID:
32049055
DOI:
10.1016/j.bpj.2020.01.008

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