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Dev Cell. 2020 Feb 10;52(3):251-252. doi: 10.1016/j.devcel.2020.01.022.

Prospero Phase-Separating the Way to Neuronal Differentiation.

Author information

1
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria.
2
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria; Medical University of Vienna, Vienna, Austria. Electronic address: juergen.knoblich@imba.oeaw.ac.at.

Abstract

Drosophila neural progenitors require the transcriptional repressor Prospero to promptly establish the neuronal fate of their daughter cells to avoid tumorigenesis. In this issue of Developmental Cell, Liu et al. (2020) find that Prospero is mitotically implanted and forms liquid-like droplets mediating HP1a condensation to permanently repress its targets.

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