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Curr Pharm Des. 2020 Feb 12. doi: 10.2174/1381612826666200212120947. [Epub ahead of print]

Formulation strategies of nano lipid carrier for effective brain targeting of anti-AD drugs.

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Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER-Guwahati), Department of Pharmaceuticals, Ministry of Chemicals & Fertilizers, Govt. of India, NH 37, NITS Mirza, Kamrup-781125, Guwahati, Assam. India.
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, India.
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, India.
Translational Bio-pharma Engineering Nano delivery Research Laboratory, Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS 38677. United States.


NLC is a next-generation lipid nanocarrier which holds many advantages over other colloidal lipid carrier system like higher drug loading, better and controlled release and enhanced stability. Owing to the unique structural composition, i.e. crystallized solid and liquid lipid blend it offers excellent biocompatibility and higher permeation across physiological membranes like BBB. Moreover, the surface of NLC can be easily modified with target-specific ligands, proteins, peptides, etc. which makes it a potential candidate for brain targeting of CNS acting drugs. NLC has found various applications in treatment of various CNS disorders including Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy, migraine, cerebral ischemia etc. Among these, the application of NLC towards the treatment of AD has been well explored in past two decades. In this piece of work, we have discussed the types of NLC, its composition, fabrication techniques, characterization, stability profile and application in the treatment of AD.


Alzheimer's disease; BBB; Brain; Lipid; Nanostructured lipid carrier

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