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Org Biomol Chem. 2020 Mar 4;18(9):1747-1753. doi: 10.1039/d0ob00172d.

Chemical synthesis of human milk oligosaccharides: lacto-N-neohexaose (Galβ1 → 4GlcNAcβ1→)2 3,6Galβ1 → 4Glc.

Author information

1
Department of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St Louis, Missouri 63121, USA. demchenkoa@umsl.edu.

Abstract

The first chemical synthesis of lacto-N-neohexaose (LNnH) has been completed using a convergent synthetic strategy. The reaction conditions and donor-acceptor combinations have been carefully refined to minimize side reactions and achieve high yields in all glycosylation steps. Lacto-N-neotetraose, another common human milk oligosaccharide, was also synthesized en route to the target LNnH.

PMID:
32048706
DOI:
10.1039/d0ob00172d

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