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Schizophr Bull. 2020 Feb 12. pii: sbaa004. doi: 10.1093/schbul/sbaa004. [Epub ahead of print]

Opposing Changes in the Functional Architecture of Large-Scale Networks in Bipolar Mania and Depression.

Author information

1
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy.
2
Ospedale Policlinico San Martino IRCCS, Genoa, Italy.
3
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
4
Brain and Consciousness Research Center, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan.
5
Graduate Institute of Mind Brain and Consciousness, Taipei Medical University, Taipei, Taiwan.
6
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Neurology, University of Genoa, Genoa, Italy.
7
University of Ottawa Brain and Mind Research Institute, and Mind Brain Imaging and Neuroethics Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada.
8
Mental Health Centre, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
9
Centre for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China.

Abstract

OBJECTIVE:

Manic and depressive phases of bipolar disorder (BD) show opposite symptoms in psychomotor, thought, and affective dimensions. Neuronally, these may depend on distinct patterns of alterations in the functional architecture of brain intrinsic activity. Therefore, the study aimed to characterize the spatial and temporal changes of resting-state activity in mania and depression, by investigating the regional homogeneity (ReHo) and degree of centrality (DC), in different frequency bands.

METHODS:

Using resting-state functional magnetic resonance imaging (fMRI), voxel-wise ReHo and DC were calculated-in the standard frequency band (SFB: 0.01-0.10 Hz), as well as in Slow5 (0.01-0.027 Hz) and Slow4 (0.027-0.073 Hz)-and compared between manic (n = 36), depressed (n = 43), euthymic (n = 29) patients, and healthy controls (n = 112). Finally, clinical correlations were investigated.

RESULTS:

Mania was mainly characterized by decreased ReHo and DC in Slow4 in the medial prefrontal cortex (as part of the default-mode network [DMN]), which in turn correlated with manic symptomatology. Conversely, depression was mainly characterized by decreased ReHo in SFB in the primary sensory-motor cortex (as part of the sensorimotor network [SMN]), which in turn correlated with depressive symptomatology.

CONCLUSIONS:

Our data show a functional reconfiguration of the spatiotemporal structure of intrinsic brain activity to occur in BD. Mania might be characterized by a predominance of sensorimotor over associative networks, possibly driven by a deficit of the DMN (reflecting in internal thought deficit). Conversely, depression might be characterized by a predominance of associative over sensorimotor networks, possibly driven by a deficit of the SMN (reflecting in psychomotor inhibition).

KEYWORDS:

bipolar disorder/regional homogeneity; degree of centrality/default-mode network; sensorimotor network

PMID:
32047938
DOI:
10.1093/schbul/sbaa004

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