Format

Send to

Choose Destination
J Pediatr Gastroenterol Nutr. 2020 Feb 7. doi: 10.1097/MPG.0000000000002634. [Epub ahead of print]

Influence of the 2012 European Guidelines in Diagnosis and Follow-up of Coeliac Children with Selective IgA Deficiency.

Author information

1
Pediatric Gastroenterology. Hospital Universitario Clínico San Carlos. Madrid. Spain.
2
Pediatric Gastroenterology. Hospital Universitario Gregorio Marañón. Madrid. Spain.
3
Pediatric Gastroenterology. Hospital Universitario Infanta Cristina. Madrid. Spain.
4
Pediatric Gastroenterology. Hospital Universitario Miguel Servet. Zaragoza. Spain.
5
Pediatric Gastroenterology. Hospital Universitario Puerta de Hierro. Madrid. Spain.

Abstract

OBJECTIVES:

To describe diagnostic criteria used in children with coeliac disease (CD) and selective IgA deficiency; to determine if the publication of the 2012 ESPGHAN criteria prompted any changes; to evaluate the evolution of serological markers.

METHODS:

Multicenter, retrospective, descriptive study of a cohort of children under 15 years with selective IgA deficiency diagnosed with CD (January 2006-December 2016). Demographic, clinical, genetic, histological and IgG-based antibodies were collected at diagnosis and follow-up.

RESULTS:

86 children were included, 60 diagnosed after the guide. Two groups were established: G1 (n = 63) and G2 (n = 23) with or without diagnostic biopsy respectively. In G1: 87.3% were symptomatic, 87.3% had HLA DQ2/DQ8 typing (all positive), all had IgG serology positive (71.5% ATG, 35% EMA, 19% DPG, 9.5% AGA) and all had villous atrophy (Marsh-Oberhuber 2-3). Follow-up data were available in 58 children, 34 after 2 years on a gluten-free diet. 52% remained ATG IgG positive despite good dietary adherence and symptom remission. Regarding G2: all were diagnosed post-2012, had typical symptoms, HLA DQ2/DQ8 positive and ATG IgG x 10 ULN. Additionally, EMA IgG was performed in 14 (60%), all positive.

CONCLUSIONS:

In our cohort of children with selective IgA deficiency and diagnosed with CD, children without a diagnostic biopsy suggests that IgG serology was considered the equivalent as IgA isotype, even when this is not addressed in the aforementioned guidelines. Great heterogeneity was observed in the IgG serology used at diagnosis. After 2 year of a gluten-free diet, half of children remained with a positive serology.

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center