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Eur J Neurol. 2020 Feb 11. doi: 10.1111/ene.14167. [Epub ahead of print]

Assessing the effectiveness of SCD-plus criteria in predicting the progression to Alzheimer's Disease: A 11-year follow-up study.

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Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy.
IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.



Subjective Cognitive Decline (SCD) is as a self-experienced decline in cognitive capacity with normal performance on standardized cognitive tests and has been shown to increase risk of Alzheimer's Disease (AD). SCD could be also related to other conditions such as normal aging, psychiatric, neurological or medical disorders. The SCD-Initiative proposed a set of features (SCD-plus) that increase the likelihood of preclinical (AD) in individuals with SCD. We aimed to assess the effect of these features on the risk of conversion from SCD to AD.


We included 150 SCD subjects which underwent extensive neuropsychological investigation, assessment of cognitive complaints and ApoE genotyping at baseline and clinical-neuropsychological follow-up for a mean time of 11 years.


During the follow-up, 20 subjects developed AD. Considering SCD-plus features, "age at onset ≥60 years" and ApoE-e4 significantly increased risk of conversion from SCD to AD. When we stratified our sample into three groups (no risk factor, one risk factor, two risk factors), proportion of conversion was statistically significantly different among the three groups.


Our model allows to stratify risk of AD in patients experiencing SCD according to age at onset and ApoE genotype.


Alzheimer’s disease; ApoE; Cognitive disorders and Dementia; Risk Factors; Subjective Cognitive Decline


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