Format

Send to

Choose Destination
Biosci Rep. 2020 Feb 28;40(2). pii: BSR20193629. doi: 10.1042/BSR20193629.

Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier.

Author information

1
Department of Pathophysiology, School of Basic Medicine, Ministry of Education Key Laboratory for Neurological Disorders, Hubei Key Laboratory for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
2
Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226000, China.

Abstract

Abnormal aggregation of pathological tau protein is a neuropathological feature of Alzheimer's disease (AD). In the AD patients, the abnormal tau accumulation first appeared in entorhinal cortex (EC) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. Here, we studied the role and mechanisms underlying periphery inflammation on brain tau transmission. By intraperitoneal injection of lipopolysaccharide (LPS) with brain medial entorhinal cortex (MEC)-specific overexpressing P301L human tau (P301L-hTau), we found that both acute and chronic administration of LPS remarkably promoted P301L-hTau transmission from MEC to the hippocampal subsets. Interestingly, the chronic LPS-induced P301L-hTau transmission was still apparent after blocking microglia activation. Further studies demonstrated that LPS disrupted the integrity of blood-brain barrier (BBB) and simultaneous intraperitoneal administration of glucocorticoid (GC) attenuated LPS-promoted P301L-hTau transmission. These data together suggest that a non-microglia-dependent BBB disruption contributes to peripheral LPS-promoted brain P301L-hTau transmission, therefore, maintaining the integrity of BBB can be a novel strategy for preventing pathological tau propagation in AD and other tauopathies.

KEYWORDS:

Alzheimers disease; blood brain barrier; lipopolysaccharides; microglia; tau transmission

PMID:
32043530
DOI:
10.1042/BSR20193629

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center