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Ann Transl Med. 2019 Dec;7(23):790. doi: 10.21037/atm.2019.11.116.

The application of single-cell sequencing technology in the diagnosis and treatment of hepatocellular carcinoma.

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Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.


Single-cell sequencing technology refers to the sequencing of the genome, transcriptome and epigenome in one single cell. Comparing to traditional histology, single-cell sequencing can reveal the genetic heterogeneity among different cells. Due to the complex pathogenesis and various pathological types of hepatocellular carcinoma (HCC), studies on the heterogeneity of tumor cells confer improvement for its clinical diagnosis, treatment and prognosis. This article summarizes the principal basis and development of single-cell sequencing technology, as well as its increasing application in the field of HCC.


Single-cell sequencing; hepatocellular carcinoma (HCC); heterogeneity

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Conflicts of Interest: The authors have no conflicts of interest to declare.

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