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Chemosphere. 2020 Feb 1;248:126092. doi: 10.1016/j.chemosphere.2020.126092. [Epub ahead of print]

Serum level of PCBs and OCPs and leukocyte telomere length among adults in Tehran, Iran.

Author information

1
Department of Environmental Health Engineering, School of Health, Arak University of Medical Sciences, Arak, Iran. Electronic address: karimibehroz@yahoo.com.
2
Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Enghelab St., Tehran, Iran.
3
Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Enghelab St., Tehran, Iran; Department of Research Methodology and Data Analysis, Institute for Environmental Research (IER), Tehran University of Medical Sciences, Kargar St., Enghelab Sq., Tehran, Iran.

Abstract

Exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) may change leukocyte telomere length (TL) at the end of the DNA sequence. The purpose of this study was to investigate the association between PCBs and OCPs exposure with TL in Tehran adult males. Whole-blood samples were randomly taken from three hundred adult males in population-based cross-section study from October 2016 to November 2017. We studied the serum levels of PCBs, OCPs as well as socio-demographic characteristics of individuals. The quantitative PCR was used to investigate the number of the telomere (T) repeats to the number of a single copy gene. We measured the effect of each PCBs and OCPs congeners on TL using linear regressions adjusted for age, BMI, smoking, and dietary patterns. The median level of the six non-dioxin-likes, five dioxin-likes PCBs three OCPs and TL in the study population were 344.5, 306.0, 45.0 ng/g lipid and 5377.7 ± 573.4 base pairs, respectively. In the adjusted model, the percent difference in the TLs with exposure to Σnon-dioxin-like PCBs, Σdioxin-like PCBs, and OCPs were 1.93 (-0.70 to 5.4), 3.4 (1.8-8.3) and -2.4 (-0.80 to -6.2), respectively. In the fourth quartile compared to the first quartile, the percent difference in the TLs due to Σnon-dioxin-like PCBs, Σdioxin-like PCBs, and OCP exposure were 0.01 (-0.01 to 0.05), 10.3 (2.9-18.1) and -0.20 (-0.10 to -4.5), respectively. Exposures to ndl-PCBs and dl-PCBs (except for PCB28) were related to longer TLs, but OCPs exposure can be related to telomere shortening.

KEYWORDS:

Organochlorine pesticides (OCPs); Peripheral blood leukocytes; Polychlorinated biphenyls (PCBs); Telomere length (TL)

Conflict of interest statement

Declaration of competing interest The authors declare no financial conflict of interest.

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