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J Diabetes. 2020 Feb 10. doi: 10.1111/1753-0407.13025. [Epub ahead of print]

Current Status of Metformin in addition to Insulin Therapy in Adult Patients with Type 1 Diabetes Mellitus: an Analysis from the Guangdong T1DM Translational Medicine Study.

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the Third Affiliated Hospital of Sun Yat-sen University, Guangdong, Guangzhou, China.
the People's Hospital of Zhongshan, Zhongshan Affiliated Hospital of Sun Yat-sen University, Zhongshan, China.
the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.



Limited data on efficacy of the additional metformin therapy in patients with type 1 diabetes mellitus (T1D) under real-life conditions was available.


Patients aged ≥18 years and with the duration of T1D for at least 1 year were included in this multicenter and observational study. Patients with insulin combined with metformin therapy (MET group) were compared with those with insulin therapy only (INS group).


A total of 76 patients in MET group were compared with 655 patients in INS group. At baseline, patients in MET group were more prevalent with dyslipidemia (17.6% vs 9.0%, P = 0.006) and had higher body mass index (BMI) [(21.7 ± 3.2) kg/m2 vs (20.4 ± 2.6) kg/m2 , P < 0.001] than those in INS group. But HbA1c and daily insulin dose had no significant difference between two groups. After 1-year's follow-up, HbA1c decreased in both groups, while the daily insulin dose deceased in MET group but had no change in INS group (-0.02 IU/kg (-0.16,0.09) vs 0 IU/kg (-0.09,0.09), P = 0.029). The additional metformin therapy led to no change of BMI and weight, while the body weight was increased from (53.7 ± 8.6) kg to (55.0 ± 7.9) kg in INS group (P < 0.001).


Metformin was initiated more in T1D patients with dyslipidemia or higher BMI in current practice in China. The addition of metformin was effective in keeping weight and reducing the insulin dosage without improving of glycemic control in patients with T1D. This article is protected by copyright. All rights reserved.


Adults; Metformin; Type 1 diabetes mellitus


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