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J Clin Aesthet Dermatol. 2019 Nov;12(11):35-44. Epub 2019 Nov 1.

Stromal Vascular Fraction and its Role in the Management of Alopecia: A Review.

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Drs. Stefanis, Arenbergerova, and Arenberger are with the Department of Dermatology and Venereology, Faculty Hospital Kralovske Vinohrady and Third Medical Faculty of Charles University in Prague, the Czech Republic.
Drs. Groh and Bauer are with Bioinova, Ltd. in Prague, the Czech Republic.


Adipose cells organized in small clusters under the reticular dermis closely interact with hair follicular cells and regulate the hair cycle. Intradermal adipocyte progenitor cells are activated toward the end of the telogen phase to proliferate and differentiate into mature adipocytes. These cells, surrounding the hair follicles, secrete signaling molecules that control the progression of the hair cycle. Diseases associated with defects in adipocyte homeostasis, such as lipodystrophy and focal dermal hypoplasia, lead to alopecia. In this review, we discuss the potential influence of stromal vascular fraction from adipose tissue in the management of alopecia as well as its involvement in preclinical and clinical trials.


Adipose-derived stromal/stem cells; adipose tissue; alopecia; hair loss; stromal vascular fraction


Conflict of interest statement

FUNDING:No funding was provided for this study. DISCLOSURES:The authors have no conflicts of interest relevant to the content of this article.

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