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Front Endocrinol (Lausanne). 2020 Jan 22;10:941. doi: 10.3389/fendo.2019.00941. eCollection 2019.

The Association of Gut Microbiota With Idiopathic Central Precocious Puberty in Girls.

Author information

1
Department of Pediatrics, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China.
2
School of Statistics and Data Science, NanKai University, Tianjin, China.
3
Microbial Department, WeHealthGene Institute, Shenzhen, China.
4
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
5
Joint Laboratory of Microecology and Children's Health, Shenzhen Children's Hospital and Shenzhen WeHealthGene Co. Ltd, Shenzhen, China.
6
Department of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, China.

Abstract

Idiopathic central precocious puberty (ICPP) is a relatively common condition in preadolescent girls, and its pathogenesis remains to be uncovered. A variety of studies have highlighted the association of gut microbiota (GM) with endocrine diseases, such as obesity, which is commonly associated with ICPP. However, the relationship between GM and ICPP remains unexplored. Feces samples were collected from 25 girls with ICPP (ICPP group) and 23 healthy girls (Control group). We applied 16S rDNA sequencing to compare the GM between two groups. The ICPP group had higher GM diversity and was enriched for several GM species, including Ruminococcus gnavus, Ruminococcus callidus, Ruminococcus bromii, Roseburia inulinivorans, Coprococcus eutactus, Clostridium leptum, and Clostridium lactatifermentans, which are known to be associated with obesity and are related to the production of short-chain fatty acids. Additionally, 36 candidate GM biomarkers for patients with ICPP screening were identified with high accuracy (AUC = 0.95, 95% CI 0.88 to 1). We observed that the GM of the ICPP group was enriched for the microbial functions of cell motility, signal transduction, and environmental adaptation. Positive correlations were also detected between Fusobacterium and follicle-stimulating hormone, and Gemmiger and luteinizing hormone. This study documents relationships between GM and ICPP, and the implication of these findings remains to be determined.

KEYWORDS:

16S rDNA sequencing; gut microbota; idiopathic central precocious puberty; leptin; short chain fatty acids

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