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J Hum Reprod Sci. 2019 Oct-Dec;12(4):348-350. doi: 10.4103/jhrs.JHRS_151_18. Epub 2019 Dec 17.

Complete Androgen Insensitivity Syndrome: Dilemmas for Further Management after Gonadectomy.

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Department of Obstetrics and Gynecology, AIIMS, Jodhpur, Rajasthan, India.
Department of Paediatrics, AIIMS, Jodhpur, Rajasthan, India.


Complete androgen insensitivity syndrome is a rare condition, wherein a genetic male is phenotypically female and is raised as a female. Treatement requires timely gonadectomy, need for long term hormonal replaceent therapy, psycological and genetic counseling. The type, dose, duration of hrt is not well studied. Reproductive issues also need to be addressed in these young woman. We report here a case of complete androgen insensitivity which posed a quandary for management of long term bone health. Review of literature for management is discussed. These cases are best managed by a multi-disciplenary team comprising of gynecologist, geneticist, endocrinologist and clinical psycologist or psychiatrist.


Complete androgen insensitivity syndrome; hormone replacement therapy; partial androgen insensitivity syndrome; testicular feminization syndrome

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