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Eur J Clin Pharmacol. 1988;34(5):521-3.

The effect of a diet rich in brussels sprouts on warfarin pharmacokinetics.

Author information

1
Nutrition Laboratory, Kommunehospitalet, Copenhagen, Denmark.

Abstract

Ten healthy subjects were given 20 mg of warfarin orally before, and after a daily intake of 400 g of brussels sprouts for 2 weeks. The brussels sprouts diet stimulated warfarin disposal as evidenced by a 29% increase in mean elimination rate constant, accompanied by a 27% increase in metabolic clearance rate and a 16% decrease in plasma AUC. It is concluded that a high intake of brussels sprouts, a cruciferous vegetable, accelerates warfarin disposal, and thereby might contribute to less anticoagulation.

PMID:
3203715
[Indexed for MEDLINE]

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