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Eur J Clin Pharmacol. 1988;34(5):517-9.

Relative bioavailability of oral low dose methotrexate. A comparison of 2 different formulations.

Author information

1
Department of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Oslo.

Abstract

In 39 patients the bioavailability of methotrexate from the two tablets Emthexat 2.5 mg and Methotrexate 2.5 mg was assessed in a double-blind study after a single oral dose of 30 mg/m2 Methotrexate. There was a considerable inter-individual variation of the serum pharmacokinetics in regard to Cmax and tmax, independent on the MTX formulation. Emthexat 2.5 mg tablets and Methotrexate 2.5 mg tablets were bioequivalent according to the definition (AUCE greater than or equal to AUCM X 80%).

PMID:
3203714
DOI:
10.1007/bf01046713
[Indexed for MEDLINE]

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