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Biochim Biophys Acta Mol Basis Dis. 2020 Feb 5;1866(5):165715. doi: 10.1016/j.bbadis.2020.165715. [Epub ahead of print]

Cell cycle regulators in cancer cell metabolism.

Author information

1
Metabolism and Cancer Laboratory, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
2
Metabolism and Cancer Laboratory, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. Electronic address: Lluis.Fajas@unil.ch.

Abstract

Cancer proliferation and progression involves altered metabolic pathways as a result of continuous demand for energy and nutrients. In the last years, cell cycle regulators have been involved in the control of metabolic processes, such as glucose and insulin pathways and lipid synthesis, in addition to their canonical function controlling cell cycle progression. Here we describe recent data demonstrating the role of cell cycle regulators in the metabolic control especially in studies performed in cancer models. Moreover, we discuss the importance of these findings in the context of current cancer therapies to provide an overview of the relevance of targeting metabolism using inhibitors of the cell cycle regulation.

KEYWORDS:

Cancer; Cell cycle; Cyclin-dependent kinases; Cyclins; Metabolic adaptation; Metabolism; Mitochondria

Conflict of interest statement

Declaration of competing interest The authors have declared that no competing interests exist.

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