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Molecules. 2020 Feb 4;25(3). pii: E652. doi: 10.3390/molecules25030652.

Cannabinoids in the Pathophysiology of Skin Inflammation.

Author information

1
Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
2
Department of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, Romania.
3
Department of Dermatology, "Carol Davila" Central Military Emergency Hospital, 010825 Bucharest, Romania.
4
Immunology Department, "Victor Babes" National Institute of Pathology, 050096 Bucharest, Romania.
5
Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania.
6
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
7
Department of Dermatology, "Prof. N. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania.
8
Gastroenterology and Internal Medicine Clinic, Carol Davila University Central Emergency Military Hospital, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
9
Department of Oral and Maxillofacial Surgery, "Carol Davila" Central Military Emergency Hospital, 010825 Bucharest, Romania.
10
Faculty of Medicine, "Titu Maiorescu" University, 031593 Bucharest, Romania.

Abstract

Cannabinoids are increasingly-used substances in the treatment of chronic pain, some neuropsychiatric disorders and more recently, skin disorders with an inflammatory component. However, various studies cite conflicting results concerning the cellular mechanisms involved, while others suggest that cannabinoids may even exert pro-inflammatory behaviors. This paper aims to detail and clarify the complex workings of cannabinoids in the molecular setting of the main dermatological inflammatory diseases, and their interactions with other substances with emerging applications in the treatment of these conditions. Also, the potential role of cannabinoids as antitumoral drugs is explored in relation to the inflammatory component of skin cancer. In vivo and in vitro studies that employed either phyto-, endo-, or synthetic cannabinoids were considered in this paper. Cannabinoids are regarded with growing interest as eligible drugs in the treatment of skin inflammatory conditions, with potential anticancer effects, and the readiness in monitoring of effects and the facility of topical application may contribute to the growing support of the use of these substances. Despite the promising early results, further controlled human studies are required to establish the definitive role of these products in the pathophysiology of skin inflammation and their usefulness in the clinical setting.

KEYWORDS:

cannabinoids; cell signaling; dermatology; inflammation; inflammatory disorders; skin cancer

PMID:
32033005
DOI:
10.3390/molecules25030652
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