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Expert Opin Investig Drugs. 2020 Feb 7. doi: 10.1080/13543784.2020.1727885. [Epub ahead of print]

CTLA4-Ig (abatacept): a promising investigational drug for use in type 1 diabetes.

Author information

1
Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, Qatar.
2
Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
3
Sustainable Development, College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar.

Abstract

Type-1 diabetes (T1D) is an autoimmune disease that results from the destruction of insulin-producing beta cells in the pancreas; it leads to the under-or nonproduction of insulin. T1D is associated with numerous life-threatening micro- and macro-vascular complications and early death, hence the development of preventative strategies are a priority for research.Areas covered:The authors outline the drawbacks of available treatments for T1D and assess the three key strategies for prevention, including immunomodulatory therapies which hold the most potential. This article examines CTLA4-Ig and its efficacy and safety profiles. Finally, the pharmacokinetic parameters and pharmacodynamic markers of abatacept are shown in-vivo and in clinical trials, guiding dosage regimen recommendations for future investigational studies.Expert opinion:Immunomodulation is one of the promising strategies for decelerating the progression of beta cell destruction after the onset of T1D. It holds the advantage of specific immune modulation without systemic general immunosuppression. Preclinical and clinical studies have yielded promising data on the use of CTLA4-Ig in T1D. Variations in response to CTLA4-Ig might be partially explained by the existence of multiple T1D subtypes with varying baseline innate inflammatory/regulatory bias and the rate of C-peptide decline.

KEYWORDS:

CTLA4-Ig; T-cell co-stimulation; abatacept; autoimmune disease; beta cells; diabetes; immunomodulation; type 1 diabetes

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