Format

Send to

Choose Destination
Bone Marrow Transplant. 2020 Feb 6. doi: 10.1038/s41409-020-0818-4. [Epub ahead of print]

Supportive care during pediatric hematopoietic stem cell transplantation: beyond infectious diseases. A report from workshops on supportive care of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT).

Author information

1
Division of Pediatric Hematology-Oncology, University Hospital of Geneva, Geneva, Switzerland.
2
Hematology and Immunology Department, Robert-Debre Hospital, Assistance Publique-Hopitaux de Paris & University of Paris, Paris, France.
3
Department of Pediatric Oncology and Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
4
Department of Hematology, Immunology, Oncology and Stem Cell Transplantation, University Children's Hospital Zürich, Zürich, Switzerland.
5
Paediatric Transplant Unit, Hospital University and Polytechnic Hospital LA FE, Valencia, Spain.
6
SCT-Unit, St. Anna Children's Hospital, Medical University Vienna, Vienna, Austria.
7
Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, IRCCS, Ospedale Bambino Gesù, Rome, Italy.
8
Department of Paediatric Haematology-Oncology, Royal Hospital for Children, Glasgow, Scotland, UK.
9
Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany.
10
Clinica Pediatrica Università degli Studi di Milano Bicocca, Fondazione MBBM, Ospedale San Gerardo, Monza, Italy.
11
Institute for Transfusion Medicine and Immunohematology of Goethe University and German Red Cross Blood Service Baden-Württemberg-Hessen, Frankfurt/Main, Germany.
12
Central Hospital of Southern Pest, National Institute of Hematology and Infectious Disease, Budapest, Hungary.
13
Children's Hospital, and Pediatric Research Center, University of Helsinki, Helsinki, Finland.
14
Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia.
15
Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway.
16
Department of Pediatric Hematology, Oncology and BMT, Wroclaw Medical University, Wroclaw, Poland.
17
Department of Pediatric Hematology & Pediatric Stem Cell Transplantation Unit, Antalya & Goztepe Medicalpark Hospitals, Antalya, Turkey.
18
Department of BMT, Great Ormond Street Hospital for Children, National Health Service (NHS) Foundation Trust, London, UK.
19
Division of Molecular Hematology, Lund University, Lund, Sweden.
20
Department of Pediatrics, Oulu University Hospital, Oulu, Finland.
21
Division of Pediatric Hematology/Oncology, University Children's Hospital of Basel, Basel, Switzerland.
22
Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany.
23
Division of Pediatric Hematology and Oncology, Hospital Motol, Charles University, Prague, Czech Republic.
24
Division of Pediatric Hematology, Oncology and BMT, The Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel.
25
EBMT Paris Office, Hôpital Saint Antoine, Paris, France.
26
Department of Pediatric Oncology, Hematology and HSCT, Poznan University of Medical Sciences, Poznań, Poland.
27
Division of Pediatric Hematoloy/Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
28
Department of Pediatric Bone Marrow Transplantation Unit, MedicalPark Göztepe Hospital, Instanbul, Turkey.
29
Pediatric Hematology, Oncology and HSCT Unit, Hospital Santa Creu i Sant Pau, Barcelona, Spain.
30
Paediatric Haematology/Oncology Department, IRCCS G Gaslini, Genova, Italy.
31
Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
32
Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
33
Division of Pediatric Stem Cell Therapy, Clinic for Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
34
Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
35
Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital of Regensburg, Regensburg, Germany.
36
Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany. peter.bader@kgu.de.

Abstract

Hematopoietic stem cell transplantation (HSCT) is currently the standard of care for many malignant and nonmalignant blood diseases. As several treatment-emerging acute toxicities are expected, optimal supportive measurements critically affect HSCT outcomes. The paucity of good clinical studies in supportive practices gives rise to the establishment of heterogeneous guidelines across the different centers, which hampers direct clinical comparison in multicentric studies. Aiming to harmonize the supportive care provided during the pediatric HSCT in Europe, the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) promoted dedicated workshops during the years 2017 and 2018. The present paper describes the resulting consensus on the management of sinusoidal obstructive syndrome, mucositis, enteral and parenteral nutrition, iron overload, and emesis during HSCT.

PMID:
32029909
DOI:
10.1038/s41409-020-0818-4

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center