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J Diabetes Investig. 2020 Feb 6. doi: 10.1111/jdi.13229. [Epub ahead of print]

Flash glucose monitoring in type 1 diabetes: A comparison with Self-monitoring blood glucose.

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Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-sayama, Osaka, 589-8511, Japan.



A flash glucose monitoring (FGM) system has become available. To clarify the relation between FGM and self-monitoring blood glucose (SMBG) values, we compared the two values after simultaneous measurement, in Japanese patients with type 1 diabetes, under daily life settings.


Twenty out-patients with type 1 diabetes were analyzed. When FGM and SMBG were performed simultaneously (within ±3 minutes), the values were adopted and each FGM value was matched and compared with the corresponding SMBG value. In addition, we analyzed other cases of simultaneity defined as "within ± 2 minute", "within ± 1 minute", and "at the exact same time".


The percentage of SMBG and FGM values in the clinically acceptable zone A+B in Clarke and Consensus Error Grid analyses were 97.9% and 99.2%, respectively. Deming regression (x-axis: FGM values, y-axis: SMBG values) determined a slope of 0.9128 (95% confidence interval: 0.9008-0.9247) and an intercept of +15.94 mg/dL (95% confidence interval: 14.05-17.84). FGM values were lower than SMBG values in the lower glucose range and higher in the higher glucose range. The shorter the time lag between measurements, the higher the rate of concordance between FGM and SMBG values.


The results of this study provided evidence on the reliability of FGM in Japanese patients with type 1 diabetes in home conditions. Based on the results, if abnormal glucose value is detected by FGM, SBMG should then be used to confirm the result.


flash glucose monitoring; self-monitoring blood glucose; type 1 diabetes

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