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Mol Cell Proteomics. 2020 Feb 5. pii: mcp.RA119.001860. doi: 10.1074/mcp.RA119.001860. [Epub ahead of print]

Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases.

Author information

1
Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom.
2
Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia, Croatia.
3
Department of Glycoconjugate Biochemistry, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland, Poland.
4
Genos, Glycoscience Research Laboratory, Zagreb, Croatia, Croatia.
5
Health and Rehabilitation Research Institute, Auckland University of Technology, Auckland, New Zealand, New Zealand.
6
Chair and Department of Endocrinology, Jagiellonian University, Medical College, Krakow, Poland, Poland.
7
General Hospital "Dr. Josip Benčević", Slavonski Brod, Croatia, Croatia.
8
Genos, Glycoscience research laboratory, Zagreb, Croatia.
9
Department of Glycoconjugate Biochemistry, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland, Croatia.
10
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia, Australia.
11
Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom, United Kingdom.
12
University of Zagreb Faculty of Pharmacy and Biochemistry, Croatia glauc@pharma.hr.

Abstract

Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells glycosylation with AITD and the influence of genetic background in a case-control study with several independent cohorts and over 3,000 individuals in total. The study revealed an inverse association of IgG core fucosylation with TPOAb and AITD, as well as decreased peripheral blood mononuclear cells antennary α1,2 fucosylation in AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody-dependent cell-mediated cytotoxicity previously associated with TPOAb levels.

KEYWORDS:

Antibodies*; Antibody-dependent cell-mediated cytotoxicity (ADCC); Autoimmune thyroid disease; Fucosylation; Glycoproteins*; Glycosylation; IgG; Immunology*; Patient cohorts; Thyroid peroxidase antibodies (TPOAb)

PMID:
32024769
DOI:
10.1074/mcp.RA119.001860
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