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Cardiovasc Res. 2020 Feb 5. pii: cvaa027. doi: 10.1093/cvr/cvaa027. [Epub ahead of print]

Promise of Autologous CD34+ Stem/Progenitor Cell Therapy for Treatment of Cardiovascular Disease.

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Department of Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
The Christ Hospital Health Network/The Carl and Edyth Lindner Center for Research and Education at The Christ Hospital, Cincinnati, OH, USA.
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN USA.


CD34+ cells are hematopoietic stem cells used therapeutically in patients undergoing radiation or chemotherapy due to their regenerative potential and ability to restore the hematopoietic system. In animal models, CD34+ cells have been associated with therapeutic angiogenesis in response to ischemia. Several trials have shown the potential safety and efficacy of CD34+ cell delivery in various cardiovascular diseases. Moreover, Phase III trials have now begun to explore the potential role of CD34+ cells in treatment of both myocardial and peripheral ischemia. CD34+ cells have been shown to be safe and well-tolerated in the acute myocardial infarction, heart failure, and angina models. Several studies have suggested potential benefit of CD34+ cell therapy in patients with coronary microvascular disease as well. In this review we will discuss the therapeutic potential of CD34+ cells, and describe the pertinent trials that have used autologous CD34+ cells in no-options refractory angina, acute myocardial infarction, and heart failure. Lastly, we will review the potential utility of autologous CD34+ cells in coronary endothelial and microvascular dysfunction.


Acute Coronary Syndromes; CD34+; Cardiovascular Diseases; Coronary Endothelial Dysfunction; Coronary Microvascular Dysfunction; Endothelial Progenitor Cells; Heart Failure; Refractory Angina


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