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Am J Otol. 1988 Sep;9(5):418-22.

Clinical evaluation of medical treatment for Menière's disease, using a double-blind controlled study.

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  • 1Department of Otolaryngology, Toyama Medical & Pharmaceutical University, Japan.


There are great variations in the clinical evaluations of the effectiveness of antivertiginous drugs for Meniere's disease. In our clinical evaluation, subjective and objective signs and symptoms of 128 patients with Meniere's disease and of 98 with other peripheral vestibular disorders were analyzed in a double-blind controlled study comparing adenosine triphosphate (ATP) (300 mg) and betahistine (36 mg) each given daily for 4 weeks. The method of administration was the matched-pair-group-method for this double-blind controlled trial. The attending physicians concluded that ATP was significantly more effective than betahistine in the treatment of Meniere's disease and other peripheral vestibular disorders.

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