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Urol Ann. 2020 Jan-Mar;12(1):73-76. doi: 10.4103/UA.UA_131_19. Epub 2019 Dec 23.

Cystic trophoblastic tumor - The effect of chemotherapy in metastatic testicular germ cell tumor to retroperitoneal lymph nodes.

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Department of Histopathology, Apollo Cancer Institutes, Chennai, Tamil Nadu, India.
Department of Vascular Surgery, Apollo Cancer Institutes, Chennai, Tamil Nadu, India.
Department of Surgical Oncology, Apollo Cancer Institutes, Chennai, Tamil Nadu, India.


Cystic trophoblastic tumor is an uncommon lesion which is occasionally seen after chemotherapy in metastatic retroperitoneal lymph nodes in patients with testicular germ cell tumor. The tumor cell clusters show cystic change lined by single to multiple layers of cells with abundant dense eosinophilic vacuolated cytoplasm, large pleomorphic vesicular nuclei with smudged chromatin, and prominent nucleoli. It is important to identify this lesion as its prognosis is similar to a teratoma and does not require any additional chemotherapy.


Chemotherapy; cystic trophoblastic tumor; germ cell tumor; retroperitoneum; testicular

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