Nociceptor-Mast Cell Sensory Clusters as Regulators of Skin Homeostasis

James Meixiong; Lilian Basso; Xinzhong Dong; Nicolas Gaudenzio

doi:10.1016/j.tins.2020.01.001

Nociceptor-Mast Cell Sensory Clusters as Regulators of Skin Homeostasis

Trends Neurosci. 2020 Mar;43(3):130-132. doi: 10.1016/j.tins.2020.01.001. Epub 2020 Jan 31.

Authors

James Meixiong¹, Lilian Basso², Xinzhong Dong³, Nicolas Gaudenzio⁴

Affiliations

¹ The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
² Unité de Différenciation Epithéliale et Autoimmunité Rhumatoïde (UDEAR), UMR 1056, INSERM, Université de Toulouse, 31059 Toulouse, France.
³ The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: xdong2@jhmi.edu.
⁴ Unité de Différenciation Epithéliale et Autoimmunité Rhumatoïde (UDEAR), UMR 1056, INSERM, Université de Toulouse, 31059 Toulouse, France. Electronic address: nicolas.gaudenzio@inserm.fr.

PMID: 32014258
DOI: 10.1016/j.tins.2020.01.001

Abstract

Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.

Keywords: MrgprB2/X2, skin; Nociceptive sensory neuron; mast cell; substance P.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Homeostasis
Humans
Mast Cells*
Nociceptors*
Pain
Skin