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Trends Immunol. 2020 Jan 29. pii: S1471-4906(20)30001-6. doi: 10.1016/j.it.2020.01.001. [Epub ahead of print]

Dynamic Post-Transcriptional Events Governing CD8+ T Cell Homeostasis and Effector Function.

Author information

1
Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK. Electronic address: fiamma.salerno@babraham.ac.uk.
2
Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
3
Department of Hematopoiesis, Sanquin Research, Landsteiner Laboratory, Amsterdam University Medical Centre (UMC), Amsterdam, and Oncode Institute, The Netherlands. Electronic address: m.wolkers@sanquin.nl.

Abstract

Effective T cell responses against infections and tumors require a swift and ample production of cytokines, chemokines, and cytotoxic molecules. The production of these effector molecules relies on rapid changes of gene expression, determined by cell-intrinsic signals and environmental cues. Here, we review our current understanding of gene-specific regulatory networks that define the magnitude and timing of cytokine production in CD8+ T cells. We discuss the dynamic features of post-transcriptional control during CD8+ T cell homeostasis and activation, and focus on the crosstalk between cell signaling and RNA-binding proteins. Elucidating gene-specific regulatory circuits may help in the future to rectify dysfunctional T cell responses.

PMID:
32007423
DOI:
10.1016/j.it.2020.01.001

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