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Comp Immunol Microbiol Infect Dis. 2020 Jan 26;69:101428. doi: 10.1016/j.cimid.2020.101428. [Epub ahead of print]

Emerging Involvement of long non-coding RNAs in gastrointestinal associated inflammatory disorders.

Author information

1
Department of Medical Biotechnology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran; Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
2
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: Marzban86@gmail.com.
3
Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
4
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran; Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Gastrointestinal (GI) disorders including a wide range of infectious, inflammatory, autoimmune, etc. disorders. Inflammatory bowel and celiac disease are non-fatal but overwhelming GI associated disorders. IBD and celiac's complications, besides the great suffering, disturb the normal life of the patients and make them involved in mental and physical problems. The emerging role of genetic content is deniable for GI inflammatory disorders incidence, and long non-coding RNAs (lncRNAs) function is the recent topic for its association. Analyzing of absolute lncRNAs interference in GI inflammatory appearance remains in infancy, and more studies are requested. Here, we concisely performed a systematic review in the last knowledge up to 2020 to identify all of the significant lncRNAs associated with the initiation and progression of GI inflammatory diseases. Accordingly, this assay attempted to refer to the expression of lncRNAs changing from the normal state, discovery of genetic mechanisms, and main effectors that would trigger associated IBD and celiac expression and immune responses would be effective for therapeutic approaches. It could be useful for prognostic and diagnostic purposes of GI associated inflammatory disorders.

KEYWORDS:

Celiac; IBD; Inflammatory bowel disease; Inflammatory disease; LncRNA; Non-coding RNA

Conflict of interest statement

Declaration of Competing Interest The authors declare that there are no conflicts of interest.

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